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KMID : 0357919840180030281
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Korean Journal of Pathology
1984 Volume.18 No. 3 p.281 ~ p.287
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Ectopic ACTH Producing Peripheral Carcinoid of the Lung Associated with Cushing's Syndrome
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박인애/In Ae Park
안긍환/박성회/이상국/함의근/김주현/민헌기/Geung Hwan Ahn/Seong Hoe Park/Sang Kook Lee/Eui Keun Ham/Joo Hyun Kim/Hun Ki Min
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Abstract
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A case of peripheral carcinoid tumor of the lung associated with Cushing's syndrome
is reported.
This 31-year-old man presented Cushing's syndrome 10 years ago and underwent
bilateral adrenalectomy Cushing's syndrome was relieved postoperatively tut was
followed by pronounced hyperpigmentation 8 years later. The lung nodule which was
noticed at the 1st admission enlarged recently. Pneumonectomy specimen revealed gray
a brown well demarcated mass in the periphery of the lung. Microscopically the tumor
consisted plainly of spindle cell element. On electron microscopy membrane-bound
neurosecretory granules were identified. On PAP stain ACTH was demonstrated in the
cytoplasm.
In summary the peripheral carcinoid produced ectopic ACTH with resultant Cushing's
syndrome and hyperpigmentation.
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